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observed that the gut microbiota of diet-induced obese (DIO) mice treated with liraglutide for four weeks displayed a similar phylogenetic composition in comparison to the start of the treatment, but was characterized by a significant decrease in microbial phenotypes associated with obesity (e.g., Firmicutes Lachnospiraceae and Clostridiales ), alongside an increase in Proteobacteria (e.g., Burkholderiales bacterium YL45 ) and Akkermansia muciniphila —a species largely associated with high-fibre diets and mucosal barrier health (11, 69–71)