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Mientras que la semaglutida actúa sobre un solo receptor (el del péptido-1 similar al glucagón, o GLP-1) y la tirzepatida sobre dos (los receptores del GLP-1 y del polipéptido inhibidor gástrico, o GIP), la retatrutida recibió el apodo de "Triple G" por su capacidad para actuar sobre tres receptores hormonales (los del GLP-1, el GIP y el receptor del glucagón, o GCG)