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Dapagliflozin reduced the primary composite outcome (sustained ≥50% eGFR decline, ESKD, or death from renal or cardiovascular causes) by 39% compared to placebo [47]

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Future studies will also be required to ascertain whether pre-existing diabetic retinopathy (at different stages) represents a contraindication to the use of semaglutide or tirzepatide in patients with autoimmune diabetes