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GLP-1R agonists (GLP-1RAs), unlike the endogenous GLP-1, are engineered to resist degradation by the enzyme dipeptidyl peptidase-4 (DPP-4) resulting in longer half-lives and sustained pharmacological activity to exert therapeutic effects [48]

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For instance, the American Diabetes Association only recommends the use of GLP-1 drugs for weight loss for those with a body mass index, or BMI, of at least 30, or among those with a BMI of 27 or greater if they have at least one other condition such as type 2 diabetes, hypertension or high cholesterol