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Sin embargo, la reducción máxima de la hemoglobina A1c (HbA1c), que refleja el control glucémico promedio durante 2-3 meses, generalmente se alcanza después de 12 a 16 semanas de tratamiento continuo

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The receptor dimer then associates with ERE (Estrogen Receptor Element), this in term recruits and modulates the so-called co-regulatory proteins namely co-activators and co-repressors