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The effects of Calocurb are typically observed within an hour of consumption
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In our study, GLP-1 and its receptor agonist inhibited rat colonic circular muscle, particularly in the IBS-C group, suggesting that the high serum levels of GLP-1 and high expression of GLP-1R in the IBS-C group inhibited colonic movement to cause the dry stool and sluggish rat small intestine transit, leading to constipation
