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The most frequent adverse events were gastrointestinal: nausea, diarrhea, constipation, and vomiting, occurring in 50 to 60% of participants at higher doses
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The paraventricular nucleus of the hypothalamus (PVH) plays a particularly important role in coordination of neural signals controlling energy balance and receives direct inputs from the NTS (Cunningham and Sawchenko, 1988)
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