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The aberrant activation of hepatic FXR in gout is identified as a significant contributor to the reduction in BA synthesis
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For patients with BMI ≥35 kg/m² (regardless of comorbidities) or BMI 30-34.9 kg/m² with metabolic disease, bariatric surgery consultation may be appropriate, according to 2022 American Society for Metabolic and Bariatric Surgery guidelines
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