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The MHRA has approved Rybelsus in three tablet strengths (3mg, 7mg, and 14mg), with treatment typically initiated at the lowest dose and gradually increased to minimise gastrointestinal side effects whilst optimising glycaemic control

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Consider Sulfonylureas • Avoid combining GLP-1 and DPP-4 inhibitors Also highlights: • HbA1c targets tailored by risk • When to escalate or switch therapy • CVD risk reduction tips including statin and BP targets #DiabetesCare #Type2Diabetes #ClinicalPharmacology #Endocrinology #PrimaryCare #MedicalEducation #HbA1c #ChronicDiseaseManagement #DrMohammedAlgizy Managing Type 2 Diabetes with Evidence-Based Therapy Managing Type 2 Diabetes – A Simplified Clinical Roadmap Here’s a clear, visual guide to the stepwise approach in managing Type 2 Diabetes Mellitus (T2DM), based on evidence-based treatment pathways: Step 1: Start with Metformin If not effective: Add a second agent like SGLT2i, DPP4i, Pioglitazone, or Sulfonylurea Triple therapy and even Insulin may be needed for some patients if targets aren’t met