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This is not to say that PEGylated GLP-1R ligands cannot cross the BBB—novel GLP-1R agonist NLY01 is a PEGylated formulation reported to be effective in treating a mouse model of multiple sclerosis (MS) (102) and of PD (103) and is currently in a phase 2 clinical trial for PD treatment (104) (Table 1), highlighting the drug’s promise for potentially treating neurological disorders