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Gut IEL GLP-1R mediates local antiinflammatory actions in the small intestine by inhibiting proximal T cell receptor (TCR) signaling in a protein kinase A–dependent manner, reducing phosphorylation of ZAP70 and SLP-76, which are key signaling nodes for initiating TCR-driven cytokine expression (Figure 3)
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Ways to Reduce Irritation If your injection site reaction is causing you significant pain, rash, or itching, contact your healthcare provider
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