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The pancreas has two main functions: the first (exocrine) is to produce and secrete digestive enzymes to break down food so it can be absorbed and the second (endocrine) is to produce hormones like insulin and glucagon that regulate blood sugar levels
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As such, even when formulated with a gastric epithelial permeability enhancer (SNAC), oral doses of semaglutide totaled over a week are 36 to 49 times higher than the weekly injectable doses of semaglutide to overcome the bioavailability limitation [16]
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