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GLP-1 receptor agonist versus DPP-4 inhibitor and kidney and cardiovascular outcomes in clinical practice in type-2 diabetes - ScienceDirect

In clinical trials, side effects tended to occur within the first weeks of starting therapy and with dose escalation, but they generally improved with time on a stable dose

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Some common side effects of GLP-1 medications include: Nausea and vomiting Diarrhea Constipation Abdominal pain Loss of appetite Headaches Infection Irritation at the injection site Patients on GLP-1 therapies can also experience muscle loss or bone density loss with prolonged use, which can compound some of the natural physical changes that accompany menopause