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To distinguish between the two subclasses of ionotropic GABA receptor (GABA A and GABA C ), we tested the effects of the specific GABA A and GABA C receptor antagonists, bicuculline methiodide and TPMPA ((1,2,5,6-tetrahydropyridine-4-yl)methylphosphinic acid), respectively (Chebib, 2004)