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For example, rats administered exendin-4 into the HPCv only decrease their consumption of a high fat/sugar diet 6h after the infusion, but at the 24h timepoint chow intake is also reduced [69]

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GLP-1 R activation induces AMPK phosphorylation, and activates multiple downstream pathways through molecules such as SIRT1, p53, and peroxisome proliferator-activated receptor γ coactivator-1 (PGC1α) [131,132]