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If genuine tachyphylaxis is confirmed, strategies include dose escalation to the next tier, brief treatment breaks of 2 to 4 weeks to allow receptor resensitization, or switching to alternative GLP-1 agonists like semaglutide to provide different receptor activation patterns

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If you or someone in your family has had medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) or another endocrine neoplasia syndrome type, or other medical conditions, you should not take this medication