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Due to the limited number of studies included, it was not possible to perform more robust meta-regressions or subgroup analyses

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The Jastreboff Phase 2 trial randomised 338 adults with body mass index ≥30 (or ≥27 with at least one weight-related condition) to retatrutide 1, 4, 8, or 12 mg subcutaneously once weekly, or placebo, for 48 weeks