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However, DiRenzo also noted a common disadvantage: “Infection is also a concern.” The first drug targeting this pathway is iscalimab (Novartis), a fully human Fc-silenced IgG1 anti-CD40 antibody
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Manufacturing Capacity and Supply Chain Investment: In a bid to avoid previous shortages of injectable GLP-1s, Eli Lilly has amassed a $1.5 billion pre-launch inventory of its oral weight loss drug orforglipron ahead of FDA decision expected in April 2026 [4]
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