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First, the large molecular size of the homodimer (approximately 63 kDa) exceeds the glomerular filtration threshold, dramatically reducing renal clearance compared to the small native GLP-1 peptide (approximately 3.3 kDa)
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While the clinical trials show a reduction in blood pressure and unhealthy blood fats, retatrutide is associated with a modest increase in resting heart rate of approximately 2–4 beats per minute
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