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Hydrophobic scaffolds, for instance, the 2-cyanopyrrolidine moiety of vildagliptin, trifluoro benzene, and thiazolidine of teneligliptin bind to S 1 pocket (catalytic Ser630), whereas lesser hydrophobic moieties like tetrahydro-triazolopyrazine of sitagliptin, 3-aminopiperidine of sitagliptin seen to bind with S 2 pocket of DPP-4

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