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The dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist tirzepatide: a novel cardiometabolic therapeutic prospect | Cardiovascular Diabetology | Springer Nature Link
The potency of GLP-1 RA after Fc fusion is another concern, as linking the GLP-1 analog with the IgG1 hinge region directly results in a severe loss of potency, suggesting a suitable spacer is needed for potency retention [86]
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Size:Small ~6 cm
[11] [1] In some participants, liver fat was reduced to below the 5% threshold conventionally used to define hepatic steatosis, suggesting potential resolution of fatty liver in those individuals
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