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GIP and glucagon-like peptide-1 (GLP-1), the second intestinal hormones discovered, are called incretins [21], as they improve the insulin response after oral glucose administration, compared to that obtained following intravenous administration [1,22,23]

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GLP-1 receptor agonists are peptide-based biologics that are absorbed directly into the systemic circulation from subcutaneous tissue, making them independent of intestinal absorption processes that might be affected by altered bile flow