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Nevertheless, the covalent modification of the cysteine is insufficient to explain the full extent of activity of these compounds as BETP and compound 2 have differences in their profile of intrinsic efficacy (see above) and also in their cooperative effect (Wootten et al., 2013b)

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Participants regained a mean of 11.6 percentage points (SD: 7.7) of body weight in the semaglutide arm versus 1.9 percentage points (SD: 4.8) in the placebo arm (Table S1)