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Users report several physical factors that may contribute to libido changes: • Energy Levels: The caloric restriction and appetite suppression can lead to reduced energy, potentially affecting sexual desire [11] • Digestive Effects: Common side effects like nausea and gastrointestinal discomfort may impact sexual interest • Blood Flow Changes: The medication's effects on vascular function might influence sexual response, particularly in reproductive tissues ‍ Research suggests these effects vary among individuals, with some experiencing improvements in sexual function due to better metabolic health, while others report decreased libido

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One monkey from the AMG 133 0.25 mg kg −1 group and two monkeys from the AMG 133 0.75 mg kg −1 group were excluded from the study/data analysis due to loss of exposure (antidrug antibody-mediated clearance)