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ROS includes a combination of the superoxide anion (O 2 − ), hydroxyl (OH − ), hydroperoxyl (OOH − ), peroxyl (ROO·), and alkoxyl (RO·) radicals, non-free radicals include hydrogen peroxide (H 2 O 2 ), hypochlorous acid (HOCl), and RNS mainly include nitric oxide (NO·), peroxynitrite (ONOO·) nitrogen dioxide (NO 2 ), ozone (O 3 ), and singlet oxygen (O 2 ) [44]