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Agonist-internalised GLP-1R colocalises with transferrin, a marker for recycling (92), and about 10 to 30% of internalised GLP-1R returns to the cell surface per hour after exendin-4 or GLP-1 treatment, respectively (87)
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This modular strategy could help manufacturers leverage the advantages of a well-established process (SPPS) while minimizing its operational risks
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