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Alluding to the deflation and sagging that can accompany rapid weight loss, the term first penetrated the zeitgeist (or at least our Google search bars) in January 2023 when The New York Times announced: โThose Weight Loss Drugs May Do a Number on Your Face.โ The next spike in curiosity about the phrase came three months later, coinciding directly with a Hollywood Reporter piece on the rise of a related phenomenon: โOzempic body.โ As the medications melted away fat, people were confronting flaccid skin that no longer fit their frames
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Fluid Retention and Heart Failure with Concomitant Use of PPAR-gamma Agonists: Fluid retention and heart failure can occur with concomitant use of thiazolidinediones (TZDs), which are PPAR-gamma agonists, and insulin, including NovoLog ยฎ