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The authors explain that, while some patients will not necessarily require the higher magnitudes of weight reduction to see clinical benefits overall, these findings support the clinical relevance of the current study as the majority of participants receiving tirzepatide (65%) were able to achieve at least 15% weight loss versus 40% for semaglutide
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The adverse effects of DPP-4is are mainly related to gastrointestinal tract discomforts (e.g., nausea, diarrhea), pancreatitis, and skin reactions (e.g., rash, angioedema, pruritus) [82]
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