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Furthermore, GLP-1 and glucose-dependent insulinotropic polypeptides have been shown to induce substance P release from sensory nerves expressing TRPV1 and TRPA1, broadening the potential pain modulation mechanisms of GLP-1 and suggesting their application in peripheral pain management 64

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This is also the honest moment to ask a harder question: if you’ve lost less than 5% of your starting body weight by week 12, you may be in the 15 to 20% of patients who are limited Ozempic responders