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Amongst people with HF, up to 50% are estimated to have type 2 diabetes and, vice versa, around 20% of the over 500 million people living with type 2 diabetes have been shown to have comorbid HF (Khan et al., 2020)

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The initial release of the SUSTAIN and PIONEER phase III clinical trials established its landmark importance in treating type 2 diabetes mellitus (T2DM) and obesity ( 3.3.1 Quantified pancreatic beta (β)-cell mass (BCM) in diabetes It is well known that a decrease in pancreatic islet beta cells causes diabetes (Table 4)