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The authors also stressed that the use of these medications should be viewed in a broader health context, including issues such as access, affordability, and insurance coverage, so that existing health inequities are not made worse
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A GIP-heavy profile may improve insulin sensitivity and tolerability A glucagon-leaning profile may increase energy expenditure but affect side effects A more balanced profile may aim for smoother overall metabolic response For retatrutide, published research suggests a strong GIP bias with moderate GLP-1 and glucagon activity
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