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However, there was no evidence of alterations to beta cell mass in beta cell‐specific β‐arrestin‐1 or ‐2 knockout mice, albeit with the caveat that effects of chronic GLP‐1 agonist treatment were not tested in these studies (Barella et al., 2019

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Remaining Scope for Side-Effect Improvement Retatrutide is a triple-action therapy that, like Lilly’s Mounjaro and Zepbound drugs, targets glucagon-like peptide-1, or GLP-1, and glucose-dependent insulinotropic polypeptide, or GIP, while also acting on the glucagon receptor