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It acts on pancreatic beta cells, promoting proliferation and inhibiting apoptosis ( in vitro cell culture experiments have confirmed that the correlation between GLP-1RA and pancreatic cancer may be related to its ability to induce phenotypic transformation of pancreatic exocrine cells into pancreatic endocrine cells ( However, whether GLP-1RA induces pancreatitis or pancreatic cancer by affecting the expression level of related genes in the pancreas or by regulating the secretion of pancreatic enzymes is still inconclusive
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