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(2025) reported that over a 72 week period of use that Mounjaro could be responsible for a reduction in muscle mass of 10.9% (the equivalent of 5 years of aging) Supervised programs enhance fat loss while preserving muscle better than unsupervised exercise (Hansen et al., 2020)

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A patient with significant metabolic dysfunction might benefit from standard-dose semaglutide or tirzepatide's stronger appetite suppression