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Hypothyroidism slows metabolic rate by 10-40%, making calorie restriction alone ineffective for many patients—GLP-1 therapy addresses this by reducing appetite and improving metabolic flexibility without forcing extreme dietary restriction

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Key Findings Summary Weight Loss: Semaglutide 2.4 mg weekly produces mean weight loss of 14.9-17.4% across the STEP trial program, with approximately one-third of patients achieving ≥20% weight loss