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Single‐Administration Self‐Boosting Microneedle Patch for the Treatment of Obesity - Singh - 2024 - Advanced Therapeutics - Wiley Online Library

To test whether leptin alters the activity of postsynaptic neurons in the PVH that receive GLP-1 inputs, we used whole-cell patch-clamp electrophysiology to record miniature excitatory postsynaptic currents (mEPSCs) from PVH neurons that express GLP-1 receptors (GLP-1 R), visualized by crossing Glp1r-Cre mice with the Cre-dependent fluorescent reporter tdTomato in leptin-deficient mice (GLP-1 R-Cre::tdTom::Lep ob/ob mice)

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DNJ is a powerful alpha-glucosidase inhibitor