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ApoC-III inhibits lipoprotein lipase and delays triglyceride-rich lipoprotein clearance, so its reduction may explain much of the triglyceride-lowering effect Small dense LDL: Limited data suggest a shift from small dense LDL particles (more atherogenic) toward larger, more buoyant LDL particles, consistent with the triglyceride reduction and improved metabolic profile Lipoprotein(a): Available data don't show a significant effect of tirzepatide on Lp(a) levels, which is consistent with other GLP-1 agonists Comparison With Other GLP-1 Agonists Tirzepatide's lipid effects appear to be more pronounced than those of GLP-1-only agonists

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Cardioprotective and Vasodilatory Actions of Glucagon-Like Peptide 1 Receptor are Mediated Through Both Glucagon-Like Peptide 1 Receptor-Dependent and -Independent Pathways