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DPP-4 is an integral membrane protein which has a widespread distribution, being expressed in numerous tissues including intestinal and renal brush border membranes, vascular endothelium, the liver and pancreas, glandular epithelial cells, and by cells of the immune system (where it is also known as the T-cell differentiation antigen, CD26)
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Conversely, IR contributes to reduced dopamine transporter expression coupled with increased excitatory glutamatergic input, elevating extracellular dopamine levels
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