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Systemic allergic reactions , whilst less common, may manifest as: Widespread urticaria (hives) – raised, itchy welts that can appear anywhere on the body Generalised pruritus (itching) without visible rash Maculopapular rash – flat red areas with small raised bumps Angioedema – deeper swelling, particularly around the face, lips, or throat It is important to distinguish between common injection site reactions and genuine allergic responses