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FIGURE 3 2.2.1 PINK1/Parkin-mediated mitophagy Under normal conditions, PINK1 (PTEN-induced kinase 1) is continuously degraded in healthy mitochondria

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The treatment period was then split into two insulin dosing stages: a capped insulin period during which total daily insulin dosage was not to exceed the dosage at randomization (weeks 8–26), followed by a period during which total daily insulin dosage was freely adjustable at the discretion of the investigator (weeks 26–52)