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Participants who received semaglutide had greater reductions in the number of heavy drinking days (41% fewer, on average) compared to those receiving placebo (26%.) The amount of alcohol consumed over the prior 30 days dropped by over 70% in the semaglutide group (from 78 ounces of 100% alcohol at baseline—the equivalent of 130 shots of 80-proof spirits over 30 days—to 23 ounces, or about 39 shots)