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Duration matters significantly: short-term prednisone courses (10–14 days) create minimal metabolic conflict, while chronic use (months or years) substantially undermines semaglutide's effectiveness

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“With trends of increasing GLP-1 prescription cost and volume, policymakers must grapple with the question of whether the Commonwealth can handle these costs in the short term,” David Cutler, HPC commissioner and Harvard University applied economics professor, said in a statement