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Analyzing molecular recognition of retatrutide by GLP-1R, GIPR and GCGR highlights that the triple agonism is achieved through a combination of maintaining common interactions with conserved residues and accommodating receptor-specific residues with variable contacts primarily in the upper half of the TMD pocket (Fig

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One of those inspired by their method was Ellis Samols (figure 11), a young South African medical graduate from the University of Cape Town who took the opportunity of his honeymoon in New York, in 1959, to learn it from Berson and Yalow