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The restoration of efficient calcium handling, particularly through preserved SERCA2a function [57,59] and reduced RyR2-mediated calcium leak [54,60], directly addresses the diastolic dysfunction that characterizes many heart failure phenotypes, especially HFpEF [57,58] (Figure 1 and Figure 3)

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provides sodium, electrolytes, and a small amount of protein without requiring eating Avoid: fried foods, red meat, strong spices, heavily sauced dishes, and anything with a strong cooking smell on injection day