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The research on tirzepatide in CKD patients is encouraging, showing kidney-protective effects, but individual responses vary

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65 In a meta-analysis by He et al, which included 76 RCTs covering more than 100,000 overweight or obese individuals, GLP-1 RA use was reported to increase the risk of gallbladder stones or biliary tract disease by 37% (RR 1.37 [95% CI 1.23–1.52])