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Rebound weight gain after stopping semaglutide or tirzepatide is real, but it's not because the body is “damaged”—it reflects how the body adapts after weight loss. When the medication is stopped, hunger

"You end up feeling less hungry as a result," says Ali

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Similarly, NICE Technology Appraisal 664 recommends liraglutide 3.0 mg (Saxenda®) with more restrictive criteria, including a BMI threshold of 35 kg/m² (or 32.5 kg/m² in certain ethnic groups) plus prediabetes and high cardiovascular risk

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