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The follow up period used to examine outcomes irrespective of ongoing use of the medication (emulating a modified intention-to-treat analysis of a clinical trial), started from the index date, and continued until study end (October 30, 2021), death, or initiation of a GLP1-RA in the DPP4i group, whichever came first (Fig
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Furthermore, liraglutide exerted anti-catabolic activity by significantly decreasing the activities of metalloproteinases and aggrecanases, a family of catabolic enzymes involved in cartilage breakdown in vitro