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“It’s just a coincidence that they found an effect in diabetes first.” Kariya and other companies are now pursuing the use of these drugs to treat neurodegeneration

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Administration of a CCK agonist restores reduced fat-induced GIP secretion in GPR120 KO mice, but not in GPR40 KO mice, suggesting that GPR120 regulates fat-induced GIP secretion via CCK, a hormone that regulates bile release and subsequent triglyceride digestion [54] (Fig