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Timing Considerations: Weaning, Treatment Goals, and Clinical Planning For individuals on GLP-1 therapy who become pregnant or plan to breastfeed, many providers recommend discontinuing treatment and restarting after weaning
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For GLP-1, the review confirmed insulinotropic effects on ฮฒ-cells during hyperglycaemia, glucagonostatic effects on ฮฑ-cells during hyperglycaemia (indirect, via somatostatin and insulin), gastric emptying delay, CNS appetite suppression, and indirect promotion of lipolysis via increased sympathetic activity