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The risk of bias was categorized as low, high or unclear, under the guidance of the Cochrane Handbook ( The risk of bias in all included studies is shown in Figure 2, Figure 3

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Oral semaglutide has proven to be noninferior to placebo in high-risk patients in a pre-approval study (30), and a larger trial to evaluate the long-term cardiovascular benefit of oral semaglutide is ongoing (NCT03914326)